Myelofibrosis: Testing RVU120

We are studying the investigational drug RVU120 for patients with myelofibrosis to see if it helps reduce cancer symptoms and improve treatment outcomes. This trial will also assess its safety and effectiveness when used alone or with another medication.

Efficacy phase (II)No Placebo Investigational Medicines OralHematology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Fem7

Jakavi

Jakavi is a medicine used to treat certain serious blood disorders that affect bone marrow and blood cell production.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Estradiol

Estradiol is a hormone used to replace low estrogen and relieve menopausal symptoms.

Methyldibromo Glutaronitrile

Methyldibromo glutaronitrile is a preservative used to prevent bacteria and mold growth in cosmetics and personal care products.

Ruxolitinib

Ruxolitinib is a substance that blocks cell signals to reduce abnormal blood cell growth and inflammation in certain bone marrow disorders.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Sel120

Dihydro-9-methyl-2-(1-piperazinyl)-4h-imidazoquinoline

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Activelle

Activelle Low

Activelle Minor

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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IRCCS Azienda Ospedaliero Universitaria di Bologna - Policlinico S. Orsola-Malpighi

Dipartimento Malattie Oncologiche ed Ematologiche

Bologna, Italy

Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia

Oncology

Brescia, Italy

Azienda Ospedaliero Universitaria Policlinico G Rodolico San Marco Di Catania

UO di Ematologia con TMO

Canalicchio, Italy

Sponsor: Ryvu Therapeutics S.A.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.