Narcolepsy with Cataplexy
Narcolepsy with cataplexy is a neurological disorder that affects the brain's ability to regulate sleep-wake cycles, leading to excessive daytime sleepiness and sudden muscle weakness triggered by strong emotions.
Narcolepsy and Idiopathic Hypersomnia: ORX750 Study
We are testing a new medication, ORX750, to see if it is safe and well-tolerated in people with narcolepsy and idiopathic hypersomnia. This study will help us understand how the drug works in the body.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Idiopathic Hypersomnia
Idiopathic hypersomnia is a sleep disorder characterized by excessive daytime sleepiness despite getting enough sleep at night, often leading to prolonged sleep episodes and difficulty waking up.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you between 18 and 65 years old?
- Do you have Narcolepsy Type 1, Narcolepsy Type 2, or Idiopathic Hypersomnia?
- Are you currently taking any medications for narcolepsy or idiopathic hypersomnia?
- Do you have any significant medical conditions like heart, lung, or kidney disease?
- Do you have any other medical disorder that causes excessive daytime sleepiness?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Orx750
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Centre Hospitalier Universitaire De Bordeaux
Plateforme de recherche Neuropsychopharmocologique
Bordeaux, France
Centre Hospitalier Universitaire De Montpellier
Unité des Troubles du Sommeil, Département de Neurologie
Montpellier, France
Azienda Ospedaliera Policlinico Universitario Tor Vergata
UOC Neurologia/Neurofisiopatologia
Ciampino, Italy
Sponsor: Centessa Pharmaceuticals UK Limited
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.