Neuroblastoma: Innovative Stem Cell Transplant and Immunotherapy

We are studying a new stem cell transplant method followed by immunotherapy for children with relapsed or resistant high-risk neuroblastoma. This trial aims to evaluate the safety and effectiveness of this approach in improving treatment outcomes.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Fludarabina Accord
Fludarabina Accord is a chemotherapy medicine used to treat certain blood cancers, such as chronic lymphocytic leukemia.
Grafalon
Grafalon is a medicine that weakens the immune system to help prevent and treat rejection after organ transplants.
Melfalan Tillomed
Melfalan Tillomed is a chemotherapy medicine used to treat multiple myeloma and certain types of ovarian and other cancers.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Anti-T Lymphocyte Immunoglobulin For Human Use
Anti-T lymphocyte immunoglobulin is a preparation of antibodies that reduces activity of immune T cells to prevent or treat organ transplant rejection.
Dinutuximab Beta
Dinutuximab beta is an antibody that helps the immune system attack high-risk neuroblastoma, a type of childhood cancer.
Fludarabine Phosphate
Fludarabine phosphate is used to treat certain blood cancers, especially chronic lymphocytic leukemia and some lymphomas.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Aplo-Tcse Tcraß+Cd19+ Depleto
Allogeneic Peripheral Blood-Derived Nk Cells
Allogeneic Peripheral Blood-Derived Haematopoietic Stem Cells

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Alkeran
Bendarabin
Beneflur

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...
IRCCS Istituto Giannina Gaslini
U.O.S.D. Centro trapianto di midollo osseo
Genoa, Italy
Sponsor: IRCCS Istituto Giannina Gaslini
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.