New Surgical Treatment for Wet AMD: Vitrectomy and TPA

We are studying a new surgical approach for people with submacular hemorrhage caused by wet AMD. This trial compares it to the standard treatment to see if it improves vision and eye health.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Actilyse 10
Actilyse 10 is a medicine used to dissolve dangerous blood clots in heart attacks, some types of stroke, and serious lung clots.
Eylea
Eylea is an eye injection medicine used to treat abnormal blood vessel growth and swelling that can cause vision loss in retinal diseases.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Aflibercept
Aflibercept is a substance that blocks signals that cause abnormal blood vessel growth and leakage in the eye to treat retinal diseases.
Alteplase
Alteplase is a substance that dissolves blood clots to restore blood flow in emergencies like stroke, heart attack, or pulmonary embolism.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Actilyse
Actilyse 20
Actilyse 50

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Universitaetsklinikum Bonn AöR
Ophthalmology
Bonn, Germany
University Medical Center Hamburg-Eppendorf
Ophthalmology
Hamburg, Germany
Klinikum der Stadt Ludwigshafen am Rhein gGmbH
Ophthalmology
Ludwigshafen am Rhein, Germany

Sponsor: King's College London
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.