New Treatment for Primary CNS Lymphoma: Optimizing MATRix

We are studying a modified treatment approach for patients with newly diagnosed primary CNS lymphoma to see if it improves survival and quality of life compared to standard therapy. This trial aims to find a safer and effective way to induce remission before further treatment.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Carmustine
Carmustine is a chemotherapy medicine used to treat certain cancers, including some brain tumors and blood cancers.
Cytarabine
Thiotepa
Thiotepa is a chemotherapy medicine used to treat certain cancers and sometimes given before bone marrow transplant.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Busulfan
Busulfan is a substance used to destroy bone marrow cells before a bone marrow transplant and to treat certain blood cancers.
Carmustine
Carmustine is a substance used to treat certain cancers by damaging or stopping growth of cancer cells.
Cytarabine
Cytarabine is a chemotherapy substance used to treat certain blood cancers, especially acute leukemias.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Alexan
Ara-Cell
Aracytin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medizinische Universitaet Innsbruck
Universitätsklinik für Innere Medizin V
Innsbruck, Austria
Hanusch Krankenhaus Der Wiener Gebietskrankenkasse
3.Medizinische Abteilung – Abteilung für Hämatologie & Onkologie
Vienna, Austria
Evangelisches Klinikum Bethel gGmbH
Klinik für Innere Medizin, Hämatologie/Onkologie, Stammzelltransplantation und Palliativmedizin
Bielefeld, Germany

Sponsor: Klinikum Der Landeshauptstadt Stuttgart gKAöR
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.