Non-Small-Cell Lung Cancer: Amivantamab Treatment Study

We are studying the effects of a new antibody treatment, amivantamab, alone and with chemotherapy for patients with early-stage lung cancer. This research aims to see if it helps before surgery and how it affects tumor characteristics.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Rybrevant
Rybrevant is a medicine used to treat non-small cell lung cancers with certain genetic changes, typically after chemotherapy.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Amivantamab
Amivantamab is a substance that targets specific proteins on certain lung cancer cells to help control advanced non-small-cell lung cancer with EGFR exon 20 mutations.

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Jessa Ziekenhuis
Pneumology
Hasselt, Belgium
Universitaetsklinikum Essen AöR
West German Cancer Center
Essen, Germany
Thoraxklinik Heidelberg gGmbH
Department of Thoracic Oncology
Heidelberg, Germany

Sponsor: Universitaetsklinikum Essen AöR
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.