Non-Small Cell Lung Cancer: Osimertinib with Datopotamab Deruxtecan

We are studying the safety and effectiveness of combining osimertinib with datopotamab deruxtecan in patients with advanced non-small cell lung cancer that has an EGFR mutation. This trial aims to see if the combination works better than osimertinib alone.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Tagrisso
Tagrisso is a cancer medicine used to treat certain non-small cell lung cancers that have specific gene changes.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Datopotamab Deruxtecan
Datopotamab deruxtecan is an antibody-based substance that targets a protein called TROP2 to deliver chemotherapy directly to certain solid tumors.
Osimertinib
Osimertinib is a targeted cancer treatment that blocks a specific protein to treat certain non-small cell lung cancers caused by gene changes.

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Institut De Cancerologie De L Ouest
Departement d'Oncologie médicale
Avignon, France
Institut Curie
Oncologie Medicale
Paris, France
Centre Hospitalier Regional De Marseille
Service d'Oncologie Multidisciplinaire et Innovations Thérapeutiques
Septèmes-les-Vallons, France

Sponsor: AstraZeneca AB
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.