Non-Small Cell Lung Cancer: Sigvotatug Vedotin with Pembrolizumab

We are studying a new treatment combining sigvotatug vedotin with pembrolizumab for patients with advanced non-small cell lung cancer that has high PD-L1 levels. The goal is to see if this combination works better than pembrolizumab alone.

>2 years 6-10 visits Confirmation phase (III)Post-Trial Drug Access No Placebo Cost Reimbursement Partially Remote Standard Medicines InjectionOncologyPulmonology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Keytruda

Keytruda is a cancer medicine that helps the immune system find and fight tumor cells.

Vidotin

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Pembrolizumab

Pembrolizumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein called PD-1.

Perindopril Tert-Butylamine

Perindopril tert-butylamine is a substance that helps lower high blood pressure and protect the heart.

Tisotumab Vedotin

Tisotumab vedotin is a substance that targets certain cancer cells and delivers a cell-killing agent to treat tumors, especially advanced cervical cancer.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Cogyr

Coverex

Coverex Forte

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Graz

Universitätsklinik für Innere Medizin Klinische Abteilung für Onkologie

Graz, Austria

Stadt Wien Wiener Gesundheitsverbund

Abteilung für Innere Medizin und Pneumologie

Langenzersdorf, Austria

Ordensklinikum Linz GmbH

Pneumologie

Linz, Austria

Sponsor: Pfizer Inc.

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.