Systemic Mastocytosis
Systemic mastocytosis is a rare condition where there is an abnormal increase in mast cells in the body, which can lead to various symptoms such as skin rashes, abdominal pain, and allergic reactions.
NonAdvanced Systemic Mastocytosis: Bezuclastinib Study
We are testing a new oral medication, bezuclastinib, to see if it is effective and safe for patients with NonAdvanced Systemic Mastocytosis. This study compares the medication to a placebo to understand its potential benefits.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you diagnosed with indolent systemic mastocytosis, smoldering systemic mastocytosis, or bone marrow mastocytosis?
- Do you have moderate-to-severe symptoms related to your condition?
- Is your performance status rated between 0 and 2 (meaning you are fully active or only slightly limited in activities)?
- Have you had any significant bleeding event in the last 30 days?
- Are you taking more than 10 mg of prednisone or its equivalent daily?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Cgt9486
Dimethyl N-(2-Phenyl-1h-Pyrrolo[2,3-b]Pyridin-5-Yl)-1h-Pyrazole-5-Carboxamide
What similar medicines might you know?
Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.
Abidec Multivitamin
Aneurine Co. Forte
Anoveb
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Johannes Kepler University Linz
Department of Hematology and Internal Oncology
Linz, Austria
Medical University Of Vienna
Vienna: Department of Medicine I, Division of Hematology and Hemostaseology
Vienna, Austria
Centre hospitalier universitaire de Tivoli Institut medical des Mutualites socialistes
Onco-Haematology
Haine-Saint-Pierre, Belgium
Sponsor: Cogent Biosciences Inc.
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.