NRAS Mutant Melanoma: Naporafenib + Trametinib Study

We are testing a new combination therapy for patients with previously treated NRAS mutant cutaneous melanoma. The goal is to see if it works better than standard treatment options in improving survival and managing the disease.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Dacarbazine Medac
Dacarbazine Medac is a chemotherapy medicine used to treat certain types of cancer, including melanoma and Hodgkin lymphoma.
Doxy-M-Ratiopharm
Doxy-M-Ratiopharm is an antibiotic medicine used to treat a range of bacterial infections.
Hydrocortisone 1%w/W Cream Pinewood Laboratories
Hydrocortisone 1% cream is used to relieve itching, redness, and swelling from minor skin rashes, eczema, insect bites, and other irritations.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Dacarbazine
Dacarbazine is a chemotherapy substance used to treat certain cancers, including melanoma and Hodgkin lymphoma.
Dacarbazine Citrate
Dacarbazine citrate is an anticancer substance used to treat certain cancers, including melanoma and Hodgkin lymphoma.
Doxycycline Monohydrate
Doxycycline monohydrate is an antibiotic substance used to treat various bacterial infections, including respiratory infections, acne, and tick-borne illnesses.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Naporafenib
Mekinist

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abix
Acecort
Actidox

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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UZ Brussel
Oncology
Ganshoren, Belgium
Universitair Ziekenhuis Gent
Oncology
Ledeberg, Belgium
Cliniques Universitaires Saint-Luc
Oncology
Sint-Stevens-Woluwe, Belgium

Sponsor: Erasca Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.