Obstructive Colon Cancer: Neoadjuvant Chemotherapy Study

We are studying whether two chemotherapy regimens can improve treatment outcomes for patients with obstructive colon cancer after colostomy. The goal is to see if starting chemotherapy before surgery leads to better recovery and survival rates.

>2 years 11-15 visits Confirmation phase (III)No Placebo Cost Reimbursement Standard Medicines Oral InjectionGastroenterologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Eloxatine

Eloxatine is a chemotherapy medicine used to treat colorectal cancer.

Elvorine

Fluorouracile Accord

Fluorouracile Accord is a chemotherapy medicine used to treat several types of cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Calcium Levofolinate

Calcium levofolinate is a substance that helps protect healthy cells during some cancer treatments and restores folate levels.

Capecitabine

Capecitabine is a substance that helps stop certain cancers from growing, commonly used for breast and colorectal cancer.

Fluorouracil

Fluorouracil is a substance used to treat cancer by stopping the growth of cancer cells.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

5-Fluorouracil

5-Fluorouracil Ebewe

5-Fluorouracil Sandoz

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Groupe Hospitalier Diaconesses Croix Saint Simon

Oncologie médicale

Bagnolet, France

Centre Hospitalier Simone Veil De Beauvais

chirurgie digestive

Beauvais, France

CHU Besancon

Chirurgie générale, digestive et cancérologique

Besançon, France

Sponsor: Centre Hospitalier Universitaire Rouen

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.