Opioid Use Disorder: Daridorexant Treatment

We are studying whether daridorexant can help reduce illicit substance use in people with opioid use disorder already on buprenorphine. The trial also looks at improvements in cravings, withdrawal symptoms, and overall treatment retention.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Quviviq
Quviviq is a medicine used to help adults with insomnia fall asleep and stay asleep.
Suboxone
Suboxone is a medicine used to treat opioid addiction by reducing cravings and withdrawal symptoms.
Subutex
Subutex is a medicine used to treat opioid addiction by reducing withdrawal symptoms and cravings.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Buprenorphine
Buprenorphine is a substance that eases opioid withdrawal and reduces cravings to help people recover from opioid dependence.
Buprenorphine Hydrochloride
Buprenorphine hydrochloride is a substance that eases opioid withdrawal and cravings to support people managing opioid dependence.
Daridorexant
Daridorexant is a substance that helps people with insomnia fall asleep and stay asleep by blocking wake-promoting brain receptors.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acimaphin
Acimaphin
Acinorphin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Region Skane Skanes Universitetssjukhus
Beroendecentrum Malmö
Dalby, Sweden
Region Joenkoepings Laen
Beroendemottagningen Psykiatriska kliniken
Jönköping, Sweden
Region Oestergoetland
Psykiatriska kliniken i Linköping
Linköping, Sweden

Sponsor: Linkopings Universitet
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.