Osteogenesis Imperfecta: Romosozumab vs. Bisphosphonates

We are studying whether romosozumab can reduce fractures and improve bone density in children and adolescents with osteogenesis imperfecta compared to bisphosphonates. This trial will help us understand the safety and effectiveness of this new treatment.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Ergocalciferol Rph Pharmaceuticals
Ergocalciferol Rph Pharmaceuticals is a medicine used to raise low vitamin D levels and help maintain healthy bones.
Evenity
Evenity is a medicine that helps build bone and reduce fracture risk in postmenopausal women with osteoporosis.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Calcium
Calcium is a substance that helps build and maintain strong bones and supports normal muscle and nerve function.
Ergocalciferol
Ergocalciferol is a form of vitamin D used to raise low vitamin D levels and support bone and calcium health.
Romosozumab
Romosozumab is a substance that helps increase bone strength by stimulating bone formation and reducing bone loss to lower fracture risk in osteoporosis.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Calciferol Bbp
Calcium And Ergocalciferol Crescent Pharma
Concavit

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...
Kepler Universitaetsklinikum GmbH
Pediatrics and Adolescent Medicine
Linz, Austria
Medical University Of Vienna
Universitaetsklinik fuer Kinder- und Jugendheilkunde
Vienna, Austria
UZ Leuven
Kindergeneeskunde
Heverlee, Belgium

Sponsor: Amgen Inc.
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.