Ovarian Cancer: NIraparib and Dostarlimab Study

We are testing a new treatment combination for patients with recurrent ovarian cancer who cannot have platinum therapy. The study aims to see if this combination helps patients live longer compared to standard chemotherapy.

Confirmation phase (III)No Placebo Standard Medicines Oral InjectionGynecology and ObstetricsOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Paclitaxel

Paclitaxel is a chemotherapy medicine used to treat various types of cancer.

Topotecan

Topotecan is a chemotherapy medicine used to treat certain cancers, including ovarian and small-cell lung cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bevacizumab

Bevacizumab is a substance that blocks formation of new blood vessels to treat certain cancers and eye conditions caused by abnormal vessel growth.

Dostarlimab

Dostarlimab is a monoclonal antibody that helps the immune system attack certain cancers by blocking a protein that restrains immune response.

Doxorubicin

Doxorubicin is a chemotherapy substance used to treat various cancers by killing rapidly dividing cancer cells.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abutrax

Apexelsin

Axitaxel

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Fakultni Nemocnice Brno

Gynecologic oncology

Brno, Czechia

Fakultni Nemocnice Ostrava

Oncological gynaecology

Hlučín, Czechia

Vseobecna Fakultni Nemocnice V Praze

Gynecologic oncology

Prague, Czechia

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.