Oxygen Levels at Birth: The HiLo-Trial

We are studying whether giving very low birthweight infants 60% oxygen instead of 30% at birth can improve their development by 18-24 months. This research aims to find the best approach for resuscitating preterm infants.

Confirmation phase (III)No Placebo Partially Remote Standard MedicinesNeurologyPediatrics

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Medical Oxygen

Medical oxygen is a gas given to people who need extra oxygen, helping those with breathing problems or low blood oxygen levels.

Oxygen 100% V/V

Oxygen 100% V/V is medical oxygen used to increase blood oxygen in people with breathing problems or low oxygen levels.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Oxygen

Oxygen is a gas used to raise blood oxygen and support breathing in people with respiratory problems or low oxygen levels.

Oxygen Ph.Eur.

Oxygen is a gas used to increase blood oxygen levels and support breathing in people with respiratory distress.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Actynox

Air Synthétique Médicinal

Air Synthétique Médicinal Air Products

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Cork University Maternity Hospital

Paediatrics and Child Health

Cork, Ireland

Sponsor: University College Cork

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.