Pancreatic Cancer: Personalized FOLFIRINOX Dosing Study

We are exploring how personalized dosing of the chemotherapy drug 5-FU affects safety and treatment outcomes in pancreatic cancer patients. This study aims to find the best dosing strategy to improve effectiveness and minimize side effects.

3-6 monthsEfficacy phase (II)No PlaceboInvestigational MedicinesInjectionGastroenterologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Fluorouracil Accord
Fluorouracil Accord is a chemotherapy medicine used to treat several types of cancer.
Oxaliplatine Accord
Oxaliplatine Accord is a chemotherapy medicine used to treat colorectal and other cancers.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Calcium Folinate
Calcium folinate is a form of folate used to treat folate deficiency and reduce harmful effects of some chemotherapy.
Fluorouracil
Fluorouracil is a substance used to treat cancer by stopping the growth of cancer cells.
Irinotecan Hydrochloride Trihydrate
Irinotecan hydrochloride trihydrate is a chemotherapy agent used to treat several types of cancer, especially colorectal cancer.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Folikabi

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

5-Fluorouracil
5-Fluorouracil Ebewe
5-Fluorouracil Sandoz

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Amsterdam UMC Stichting
Clinical Pharmacology and Pharmacy
Amstelveen, Netherlands
Catharina Ziekenhuis Stichting
Clinical Pharmacy
Eindhoven, Netherlands
Leids Universitair Medisch Centrum (LUMC)
Medical Oncology
Leiden, Netherlands
Sponsor: Catharina Ziekenhuis Stichting
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.