Pancreatic Cancer: Sotorasib with Chemotherapy

We are studying the safety of combining sotorasib with standard chemotherapy for patients with advanced pancreatic cancer that has a specific genetic mutation. This trial aims to see if this combination improves treatment outcomes.

≤3 monthsSafety phase (I)No PlaceboStandard MedicinesOralInjectionGastroenterologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Calcium Folinate
Calcium folinate helps protect the body from side effects of some chemotherapy drugs and restores folate (vitamin B9) levels.
Irinotecan
Irinotecan is a chemotherapy medicine used to treat certain cancers, especially colorectal cancer.
Lumykras
Lumykras is a cancer medicine used to treat certain non-small cell lung cancers with a specific genetic change.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Calcium Folinate
Calcium folinate is a form of folate used to treat folate deficiency and reduce harmful effects of some chemotherapy.
Fluorouracil
Fluorouracil is a substance used to treat cancer by stopping the growth of cancer cells.
Gemcitabine
Gemcitabine is a substance that slows or stops cancer cell growth and is used to treat several cancers, including pancreatic and lung.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abutrax
Antrex
Apexelsin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Sainte Catherine Institut Du Cancer Avignon-Provence
Oncology
Avignon, France
Centre Hospitalier Universitaire De Bordeaux
Oncology
Bordeaux, France
Centre Hospitalier Regional Et Universitaire De Brest
Oncology
Brest, France
Sponsor: Asociacion Grupo Tratamiento De Tumores Digestivos
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.