Parkinson's Disease: AAV2-GDNF Treatment Study

We are studying a new therapy to see if it can improve motor symptoms in adults with moderate Parkinson's Disease. The trial also looks at safety and overall quality of life for participants.

>2 years Efficacy phase (II)Post-Trial Drug Access No Placebo Investigational Medicines Oral InjectionNeurology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Dopaview

Glunektik

Prohance

ProHance is a medicine given during MRI scans to make images clearer so doctors can better detect abnormalities.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Carbidopa

Carbidopa is a substance that helps Parkinson’s treatments work better by preventing levodopa from breaking down before it reaches the brain.

Fludeoxyglucose (18f)

Fludeoxyglucose (18F) is a radioactive tracer used in PET scans to highlight areas of high metabolic activity, often for detecting cancer.

Fluorodopa (18f)

Fluorodopa (18F) is a radioactive tracer used in PET scans to visualize dopamine-producing brain cells for diagnosing and evaluating Parkinson's disease.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Gluscan

Aav2-gdnf

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

[18f] Fdg

[18f] Fdg Βιοκοσμοσ

[18f] Fludeoxyglucose Biont

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Charite Universitaetsmedizin Berlin KöR

Klinik für Neurochirurgie

Berlin, Germany

Philipps-Universitaet Marburg

Klinik und Poliklinik für Neurologie

Marburg an der Lahn, Germany

Universitaetsklinikum Tuebingen AöR

Department für Neurochirurgie und Neurotechnologie

Tübingen, Germany

Sponsor: Askbio Inc.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.