Parkinson's Disease: New Approaches to Levodopa Resistance

We are studying whether the medication apomorphine or the antibiotic rifaximin can help people with Parkinson's disease who struggle with levodopa treatment. This trial aims to improve their symptoms and overall treatment response.

6-12 months ≤5 visits Efficacy phase (II)Post-Trial Drug Access Cost Reimbursement Standard Medicines Oral InjectionInternal MedicineNeurology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Dacepton

Domperidon Accord

Domperidon Accord is a medicine used to relieve nausea and vomiting and help the stomach empty.

Madopar

Madopar is a medicine used to treat symptoms of Parkinson's disease by improving movement and reducing tremors and stiffness.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Apomorphine Hydrochloride Hemihydrate

Apomorphine hydrochloride hemihydrate is a substance that rapidly restores movement during sudden 'off' episodes in Parkinson's disease.

Benserazide

Benserazide is a substance that prevents breakdown of levodopa outside the brain to increase its effect for people with Parkinson's disease.

Benserazide Hydrochloride

Benserazide hydrochloride is a substance used with levodopa to increase its availability in the brain for treating Parkinson's symptoms.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Apo-Go

Apo-Go Ampoules

Apo-Go Ampullen

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Radboud universitair medisch centrum Stichting

Department of Human Genetics

Nijmegen, Netherlands

Sponsor: Stichting Radboud University Medical Center

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.