T-cell Lymphoma
T-cell lymphoma is a type of cancer that originates in T-cells, which are crucial for the immune system. In relapsed/refractory cases, the lymphoma returns or does not respond to treatment, leading to ongoing health challenges.
Peripheral T-Cell Lymphoma: Tolinapant with Decitabine/Cedazuridine
We are studying a new treatment combining tolinapant with oral decitabine/cedazuridine for patients with relapsed or refractory peripheral T-cell lymphoma. The goal is to assess safety and effectiveness compared to the current standard treatment.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you 18 years of age or older?
- Are you currently pregnant or breastfeeding?
- Do you have a history of any type of T-cell lymphoma?
- Have you received at least two prior treatments for your cancer?
- Are you taking any medications that are strong CYP3A4 inhibitors like Ketoconazole or Clarithromycin?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Astx727
Tolinapant
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Institut Bergonie
Hematology Department
Bordeaux, France
Centre Hospitalier Universitaire De Bordeaux
Clinical Hematology Department
Canéjan, France
Assistance Publique Hopitaux De Paris
Hemato-Oncology
Igny, France
Sponsor: Taiho Oncology Inc.
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.