Persistent Atrial Fibrillation: Cryoballoon vs. Medication

We are studying whether early treatment with a cryoballoon is more effective than antiarrhythmic drugs for people with persistent atrial fibrillation. The trial also looks at how these treatments affect quality of life and healthcare needs.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Dronedarone Teva
Dronedarone Teva is a medicine used to help keep the heart beating regularly in people with atrial fibrillation or atrial flutter.
Propafenone Eg
Propafenone Eg is a medicine used to help control irregular heartbeats and restore a normal heart rhythm.
Sotalol Eg
Sotalol EG is a medicine used to treat irregular heartbeats by helping the heart beat more regularly.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Dronedarone
Dronedarone is a substance that helps maintain a normal heart rhythm in people with atrial fibrillation or atrial flutter.
Flecainide
Flecainide is a substance used to treat certain irregular heartbeats by stabilizing the heart's electrical signals.
Propafenone Hydrochloride
Propafenone hydrochloride is a substance used to treat abnormal heart rhythms by helping restore and maintain a regular heartbeat.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Arythmol
Beta-Cardone
Biosotal

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Tokuda Hospital
Clinic of Cardiology, Department of Electrophysiology
Sofia, Bulgaria
Aalborg University Hospital
Department of Cardiology
Aalborg, Denmark
Kerckhoff-Klinik GmbH
Department of Cardiology
Bad Nauheim, Germany

Sponsor: Region Oerebro Laen
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.