Plaque Psoriasis: ESK-001 Treatment Study

We are testing a new medication, ESK-001, for people with moderate to severe plaque psoriasis. The study aims to see if it works better than a placebo and an existing treatment.

6-12 months 6-10 visits Confirmation phase (III)Post-Trial Drug Access Cost Reimbursement Investigational Medicines OralDermatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Apremilast

Apremilast is a pill that helps control symptoms of psoriasis and psoriatic arthritis by reducing inflammation.

Esketex

Otezla

Otezla is a medicine used to treat plaque psoriasis and psoriatic arthritis, helping reduce skin plaques and joint pain.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Apremilast

Apremilast is a substance that reduces inflammation to help treat conditions like psoriasis and psoriatic arthritis.

Esketamine Hydrochloride

Esketamine hydrochloride is a fast-acting substance used to treat severe depression when other treatments haven’t worked.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Esk-001

Envudeucitinib

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Afimax

Aperzyx

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...

Cliniques Universitaires Saint-Luc

Dermatology

Sint-Stevens-Woluwe, Belgium

Centre Hospitalier Universitaire De Liege

Dermatology

Tilff, Belgium

Multiprofile Hospital For Active Treatment Dr. Tota Venkova AD

Department of Skin and Venereal Diseases

Gabrovo, Bulgaria

Sponsor: Alumis Inc.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.