High Triglycerides
Hypertriglyceridemia is a condition where there are high levels of triglycerides, a type of fat, in the blood. This can increase the risk of heart disease and pancreatitis.
Plozasiran for Severe Hypertriglyceridemia: SHASTA-5 Study
We are studying whether plozasiran can help adults with severe hypertriglyceridemia reduce their triglyceride levels and lower the risk of acute pancreatitis. The trial also looks at the treatment's safety and how it affects patients' overall health.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you a male or a nonpregnant female who is at least 18 years old?
- Do you have a history of high triglycerides with levels of 880 mg/dL or higher?
- Is your fasting triglyceride level 1,000 mg/dL or higher?
- Have you had at least two episodes of pancreatitis in the past year?
- Are you currently taking medications to lower your triglycerides?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Aro-apoc3
Plozasiran
Synthetic Double-Stranded Sirna Oligonucleotide
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Medical University Of Graz
Univ. Klinik für Innere Medizin Diabetes- und Stoffwechselambulanz
Graz, Austria
Konvent Der Barmherzigen Brueder
Konventhospital der Barmherzigen Brüder Linz Interne Abteilung
Linz, Austria
Klinik Hietzing
Klinik Hietzing 3. Medizinische Abteilung
Perchtoldsdorf, Austria
Sponsor: Arrowhead Pharmaceuticals Inc.
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.