Polymyalgia Rheumatica: Secukinumab Injection Study

We are studying whether secukinumab, combined with a glucocorticoid taper, can help patients with polymyalgia rheumatica achieve better remission compared to a placebo. This trial also looks at the safety and quality of life for participants.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cosentyx
Cosentyx is a medicine used to treat plaque psoriasis, psoriatic arthritis, and certain inflammatory spine conditions.
Prednisone Eg
Prednisone Eg is a steroid medicine that reduces inflammation and treats allergic, autoimmune, and other inflammatory conditions.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Prednisone
Prednisone is a steroid substance that reduces inflammation and suppresses the immune system for conditions like allergies, asthma, and autoimmune disorders.
Secukinumab
Secukinumab is a substance that blocks a specific immune protein to reduce inflammation in conditions like psoriasis, psoriatic arthritis, and ankylosing spondylitis.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Ain457

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Brucorten
Cison
Cortancyl

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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UZ Leuven
#1501: General Internal medicine
Heverlee, Belgium
Az St-Jan Brugge-Oostende A.V.
#1504: Rheumatology
Sint-Andries, Belgium
CHU De Liege
#1502: Rheumatology
Tilff, Belgium

Sponsor: Novartis Pharma AG
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.