Postoperative Pain Management: Fentanyl Nasal Spray

We are studying a fentanyl nasal spray for pain relief after orthopedic surgery, comparing it to a placebo and standard morphine treatment. The goal is to assess its effectiveness and side effects in managing pain.

≤3 monthsConfirmation phase (III)Investigational MedicinesInjectionInternal MedicineOrthopedics and TraumatologyPsychiatry

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Morphin Hameln
Morphin Hameln is a strong pain medicine used to relieve severe or intense pain.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Fentanyl Citrate
Fentanyl citrate is a potent opioid substance used to relieve severe pain, especially during surgery or for cancer-related pain.
Morphine Hydrochloride
Morphine hydrochloride is a substance that relieves severe pain by decreasing the body's perception of pain.
Morphine Sulfate Pentahydrate
Morphine sulfate pentahydrate is a substance that relieves severe pain.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Fentanyl

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Actimorph
Actiskenan
Autostrzykawka Morfina Przeciwko Bólowi, Zpsm Ravimed

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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MHAT Skin systems, Base Doganovo
Department - Doganovo - orthopaedics and traumatology
Elin Pelin, Bulgaria
Multiprofile Hospital For Active Treatment Dr. Tota Venkova AD
Department - Orthopaedics and Traumatology
Gabrovo, Bulgaria
Umbal - Prof. D-R Stoyan Kirkovich AD
Clinic of Orthopedics and Traumatology
Kardzhali, Bulgaria
Sponsor: CCDRD Cooperative Clinical Drug Research and Development AG
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.