Postoperative Pain Relief: Ibuprofen and Tramadol Combination

We are studying a new combination treatment for patients with severe pain after surgery to see if it provides better pain relief than tramadol alone and a placebo. This trial aims to assess both effectiveness and safety.

6-12 months≤5 visitsConfirmation phase (III)Investigational MedicinesInjectionInternal MedicineOrthopedics and TraumatologyOtolaryngology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Fisiológico B.Braun
Fisiológico B.Braun is a sterile saltwater solution used to clean wounds, rinse body areas, and dilute medicines for medical use.
Isotone Natriumchloridlösung Braun
Isotone Natriumchloridlösung Braun is a sterile salt (saline) solution used to replace body fluids, rinse wounds, or dilute medicines.
Tramal
Tramal is a medicine used to relieve moderate to severe pain.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Ibuprofen
Ibuprofen is a substance that reduces pain, fever, and inflammation.
Morphine Hydrochloride
Morphine hydrochloride is a substance that relieves severe pain by decreasing the body's perception of pain.
Sodium Chloride
Sodium chloride is a substance used to replace salts and fluids in the body and to clean or irrigate wounds and nasal passages.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Ibuprofen
Tramadol

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acuolens
Acuolens
Adamon

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Hospital Universitario Puerta De Hierro De Majadahonda
Anestesiología, Cuidados Críticos, Quirúrgicos y Dolor
Aranjuez, Spain
Hospital Universitario La Paz
Anestesiología y Reanimación
Chamartín, Spain
Hospital General Universitario Gregorio Maranon
Anestesia y Reanimación
Ciudad Lineal, Spain
Sponsor: Farmalider S.A.
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.