Preventing Dementia: Metformin and Lifestyle Changes

We are studying whether a combination of metformin and a structured lifestyle program can help older adults at risk for dementia improve their cognitive abilities and overall health compared to a self-guided approach.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Glucophage Xr
Glucophage XR is a medicine that helps lower blood sugar in adults with type 2 diabetes.
Metformin Hydrochloride
Metformin hydrochloride is a medicine that helps lower blood sugar in people with type 2 diabetes.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Metformin Hydrochloride
Metformin hydrochloride is a substance that helps lower blood sugar in people with type 2 diabetes.
Metformin Hydrochloride Ph. Eur.
Metformin hydrochloride is a substance that helps lower blood sugar in people with type 2 diabetes.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abmetfina Xr
Abmetfina Xr
Adimet

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Finnish Institute For Health And Welfare
Public Health and Welfare
Malminkartano, Finland
Karolinska University Hospital
Tema Inflammation och Åldrande
Solna, Sweden
Sponsor: Imperial College London
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.