Primary Biliary Cholangitis
Primary biliary cholangitis (PBC) is a rare autoimmune disease that slowly damages the bile ducts in the liver, leading to liver dysfunction and symptoms such as fatigue, itching, and jaundice.
Primary Biliary Cholangitis: Golexanolone Study
We are testing a new medication, golexanolone, for individuals with primary biliary cholangitis who have significant fatigue and cognitive difficulties. The study aims to evaluate its safety and effects on daily life and cognitive function.
3-6 months≤5 visitsSafety phase (I)Efficacy phase (II)Investigational MedicinesOralHepatologyInternal Medicine
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you at least 18 years old?
- Do you have primary biliary cholangitis (PBC)?
- Are you currently pregnant, nursing, or trying to get pregnant?
- Are you taking any medications that can cause fatigue or cognitive problems, like benzodiazepines or sedating antihistamines?
- Do you have severe liver disease, such as Child-Pugh class B or C cirrhosis?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Golexanolone
GR3027
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Universitaetsklinikum Duesseldorf AöR
Klinik für Gastroenterologie, Hepatologie & Infektiologie
Düsseldorf, Germany
ifi-Medizin GmbH
Ifi Medizin GmbH
Hamburg, Germany
Universitaet Leipzig
Clinic and Polyclinic for Oncology, Gastroenterology, Hepatology, Pneumology
Leipzig, Germany
Sponsor: Umecrine Cognition AB
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.