IgA Nephropathy
IgA Nephropathy is a kidney disease that occurs when IgA, a type of antibody, builds up in the kidneys, causing inflammation and potentially leading to kidney damage over time.
Primary IgA Nephropathy: RO7434656 Treatment Study
We are testing a new medication to see if it helps reduce protein in urine and improves kidney function in patients with Primary IgA Nephropathy at high risk of progression. The study will also evaluate safety and fatigue levels.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you pregnant or breastfeeding, or planning to become pregnant during the study or within 12 weeks after the final dose?
- Do you have high blood pressure, with systolic blood pressure over 140 mmHg or diastolic blood pressure over 90 mmHg?
- Have you been diagnosed with diabetes, or is your hemoglobin A1c 6.5% or higher?
- Have you had another autoimmune kidney disease diagnosed by a doctor?
- Are you currently taking medications like ACE inhibitors (e.g., Lisinopril, Enalapril) or ARBs (e.g., Losartan, Valsartan) for at least 90 days?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Aso Factor B
Isis 696844
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Fakultni Nemocnice Hradec Kralove
Nephrology Clinic
Hradec Králové, Czechia
Vseobecna Fakultni Nemocnice V Praze
Nephrology Clinic
Prague, Czechia
Centre Hospitalier Ardeche Nord
Service de Néphrologie - Hémodialyse
Annonay, France
Sponsor: F. Hoffmann-La Roche AG
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.