Primary Plasma Cell Leukemia: New Treatment with Bortezomib and Daratumumab

We are studying a combination of medications for people with primary plasma cell leukemia to see if it improves treatment outcomes and safety. This trial will help us understand how well this new approach works compared to current treatments.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Darzalex
Darzalex is a medicine used to treat multiple myeloma, a type of blood cancer.
Velcade
Velcade is a medicine used to treat certain blood cancers such as multiple myeloma and mantle cell lymphoma.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bortezomib
Bortezomib is a substance that blocks cellular protein breakdown to treat certain blood cancers, including multiple myeloma.
Cyclophosphamide
Cyclophosphamide is a cancer-fighting and immune-suppressing substance used to treat various cancers and some severe autoimmune conditions.
Daratumumab
Daratumumab is a substance that helps treat multiple myeloma, a blood cancer, by directing the immune system to attack the cancerous plasma cells.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abormib
Adabonib
Bortega

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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University General Hospital Of Alexandroupoli
Hematology Clinic
Alexandroupoli, Greece
Geniko Nosokomeio Thessalonikis George Papanikolaou
Hematology Clinic
Asvestochóri, Greece
Alexandra Hospital
Department of Clinical Therapeutics
Athens, Greece

Sponsor: Hellenic Society Of Hematology
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.