Progressive Glioblastoma: Perampanel Treatment Study

We are studying whether the medication Perampanel can help reduce tumor growth in patients with progressive glioblastoma before surgery. This trial also looks at quality of life and cognitive function to see how the treatment affects patients.

>2 years Efficacy phase (II)Partially Remote Standard Medicines OralNeurologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Fycompa

Fycompa is a medicine used to help control seizures in people with epilepsy.

Perampanel Eg

Perampanel Eg is a medicine used to help control seizures in people with epilepsy.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Colloidal Silicon Dioxide

Colloidal silicon dioxide is a fine, porous silica used to prevent powder clumping and improve flow and stability in pills and powders.

Perampanel

Perampanel is a substance that helps prevent seizures by calming abnormal electrical activity in the brain.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Fylepsia

Fypalan

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Charite Universitaetsmedizin Berlin KöR

Neurosurgery

Berlin, Germany

Rheinische Friedrich-Wilhelms-Universitaet Bonn

Neurooncology

Bonn, Germany

Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR

Neurosurgery

Dresden, Germany

Sponsor: Universitaetsklinikum Heidelberg AöR

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.