Propionic Acidemia: mRNA-3927 Treatment Study

We are investigating the safety and effectiveness of mRNA-3927 in individuals with propionic acidemia. The study aims to see if this treatment can reduce serious health events related to the condition.

>20 visitsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesOralInjectionEndocrinologyInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Ibuprofen
Ibuprofen is a medicine used to relieve pain, reduce inflammation, and lower fever from headaches, muscle aches, and minor injuries.
Paracetamol
Paracetamol relieves pain and reduces fever for conditions like headaches, muscle aches, and colds.
Sodium Chloride
Sodium chloride is a salt solution used to replace fluids and salts, hydrate patients, and give medicines through a vein.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Buclizine Hydrochloride
Buclizine hydrochloride is an antihistamine substance used to prevent nausea, vomiting, and motion sickness.
Cetirizine
Cetirizine is a substance that relieves common allergy symptoms like sneezing, runny nose, itchy or watery eyes, and hives.
Cetirizine Dihydrochloride
Cetirizine Dihydrochloride is an antihistamine that relieves allergic symptoms like sneezing, runny nose, itchy eyes, and hives.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Modified Messenger Ribonucleic Acid

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

200 Mg + 500 Mg
3 Months Ibuprofen Strawberry Flavour
3 Months Plus Strawberry Flavour

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Regional De Marseille
Service Neurométabolisme pédiatrique
Marseille, France
Assistance Publique Hopitaux De Paris
Service de Maladies métaboliques pédiatriques
Montrouge, France
UOC Malattie Metaboliche ed Epatologia
IRCCS Ospedale Pediatrico Bambino Gesù
Rome, Italy
Sponsor: Moderna Therapeutics Inc.
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.