Prostate Cancer: AZD5305 Treatment Study

We are studying whether AZD5305, combined with standard hormonal treatments, can improve outcomes for men with metastatic castration-sensitive prostate cancer. This trial compares the new treatment to a placebo to assess its effectiveness.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Abiraterone Teva
Abiraterone Teva is a medicine used to treat advanced prostate cancer by lowering male hormones that help the cancer grow.
Nubeqa
Nubeqa is a medicine used to treat prostate cancer that continues to grow despite hormone therapy before it has visibly spread.
Xtandi
Xtandi is a medicine used to treat prostate cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Abiraterone Acetate
Abiraterone acetate is a substance that lowers the body's male hormones to slow the growth of prostate cancer.
Darolutamide
Darolutamide is a substance that blocks male hormones' effects to help treat prostate cancer.
Enzalutamide
Enzalutamide is a substance that blocks male hormone signals to slow the growth of prostate cancer.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Bay 1841788
Saruparib

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abaxan
Abaxan
Abibam®

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Graz
Clinical Department for Oncology
Graz, Austria
Medizinische Universitaet Innsbruck
University Clinic for Urology
Innsbruck, Austria
Universitaetsklinikum Krems
Clinical Department for Internal Medicine 2
Krems an der Donau, Austria

Sponsor: AstraZeneca AB
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.