Prostate Cancer: Pembrolizumab Combination Therapy

We are studying a new combination therapy with pembrolizumab for men with metastatic castration-resistant prostate cancer. The trial aims to evaluate its safety and how well it reduces PSA levels compared to standard treatments.

Safety phase (I)Efficacy phase (II)No Placebo Cost Reimbursement Investigational Medicines Oral InjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Abiraterone

Abiraterone is a medicine used to treat prostate cancer by lowering male hormones that can make the cancer grow.

Carboplatin

Carboplatin is a chemotherapy medicine used to treat various types of cancer.

Etoposide

Etoposide is a chemotherapy medicine used to treat various types of cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Abiraterone

Abiraterone is a substance that reduces testosterone production to help manage advanced prostate cancer.

Abiraterone Acetate

Abiraterone acetate is a substance that lowers the body's male hormones to slow the growth of prostate cancer.

Belzutifan

Belzutifan is a substance that blocks a protein that helps tumors grow and is used to treat tumors linked to von Hippel-Lindau disease.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Mk-7684A

Vibostolimab

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abaxan

Abibam®

Abinone

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...

Ordensklinikum Linz GmbH

Ordensklinikum Linz GmbG Elisabethinen Abteilung für Urologie und Andrologie

Linz, Austria

SCRI CCCIT Ges.m.b.H.

Landes-Krankenhaus Salzburg Universtitätsklinik für Innere Medizin III

Salzburg, Austria

Medical University Of Vienna

Medizinische Universität Wien Universitätsklinik für Urologie

Vienna, Austria

Sponsor: Merck Sharp & Dohme LLC

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.