Pulmonary Hypertension: Long-term Safety Study

We are evaluating the long-term safety of treatments for pulmonary hypertension in participants who have previously received these interventions. This study aims to ensure ongoing safety for those already involved in related research.

Confirmation phase (III)Post-Trial Drug Access No Placebo Cost Reimbursement Partially Remote Investigational Medicines OralPulmonology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Macitentan

Macitentan is a medicine used to treat high blood pressure in the lungs.

Opsumit

Opsumit is a medicine used to treat pulmonary arterial hypertension, a type of high blood pressure in the lungs.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Macitentan

Macitentan is a substance that helps relax blood vessels in the lungs to treat pulmonary arterial hypertension.

Tadalafil

Tadalafil is a substance that helps men get and keep an erection by increasing blood flow to the penis.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Jnj-68150420

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Macitentan Amarox

Macitentan Glenmark

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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University Hospital St. Anna

Cardiology Clinic

Sofia, Bulgaria

Gottsegen National Cardiovascular Center

HU10001: Gyermekszív Központ

Budapest, Hungary

Uniwersytecki Szpital Kliniczny W Bialymstoku

Klinika Kardiologii i Chorób Wewnętrznych z Oddziałem Intensywnego Nadzoru Kardiologicznego

Białystok, Poland

Sponsor: Actelion Pharmaceuticals Ltd.

Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.