GRIN-related Disorder
GRIN-related disorder is a rare neurodevelopmental condition caused by mutations in the GRIN genes, affecting brain function and development, often leading to intellectual disability, seizures, and other neurological symptoms.
Radiprodil for Children with GRIN-related Disorder
We are studying a new medication to see if it is safe and helps reduce seizures and improve behavior in children with GRIN-related disorder. This trial aims to find the right dose and understand its effects over time.
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you between 6 months and 12 years old?
- Does the participant have at least 1 observable motor seizure per week?
- Has the participant tried at least 2 different seizure medications without good control?
- Is the participant currently taking any medications that are not allowed, like lamotrigine or felbamate?
- Is the participant's body weight 10 kg or more?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Radiprodil
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Antwerp University Hospital
Children Neurology
Wilrijk, Belgium
Centre Hospitalier Universitaire D'Angers
Neurology
Angers, France
Centre Hospitalier Universitaire De Toulouse
Pediatric Neurology
Blagnac, France
Sponsor: Grin Therapeutics Inc.
Last updated: Nov 27, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.