RAS G12C-Mutated Non-Small Cell Lung Cancer: RMC-6291 Study

We are studying a new treatment combining RMC-6291 with pembrolizumab and other therapies for patients with RAS G12C-mutated lung cancer. The goal is to evaluate safety and early signs of effectiveness.

Safety phase (I)No Placebo Investigational Medicines Oral InjectionOncologyPulmonology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Carbo-Cell

Carboplatin Ebewe Pharma

Carboplatin Ebewe Pharma is a chemotherapy medicine used to treat various types of cancer.

Carboplatin Kabi

Carboplatin Kabi is a chemotherapy medicine used to treat various types of cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Carboplatin

Carboplatin is a chemotherapy substance used to treat various cancers by damaging cancer cells and slowing tumor growth.

Cisplatin

Cisplatin is a substance used in chemotherapy to kill or stop the growth of cancer cells.

Pembrolizumab

Pembrolizumab is a substance that helps the immune system recognize and attack certain cancers by blocking a protein called PD-1.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Rmc-6291

Rmc-6236

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Alimta

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Institut Bergonie

Bordeaux, France

Hospices Civils De Lyon

Bron, France

Centre Francois Baclesse

Caen, France

Sponsor: Revolution Medicines Inc.

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.