Rectal Adenocarcinoma: Contact X-Ray Brachytherapy Study

We are studying whether adding contact X-ray brachytherapy to standard treatment can help preserve the rectum and improve survival in patients with intermediate substage rectal adenocarcinoma. We will also assess its impact on quality of life and side effects.

>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOralInjectionGastroenterologyOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Capecitabine Accord
Capecitabine Accord is an oral cancer medicine used to treat certain types of breast and colorectal cancer.
Fluorouracile Accord
Fluorouracile Accord is a chemotherapy medicine used to treat several types of cancer.
Folinate De Calcium Aguettant
Folinate De Calcium Aguettant is a medicine used to protect normal cells during some chemotherapy and to treat certain folate-related deficiencies.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Calcium Folinate
Calcium folinate is a form of folate used to treat folate deficiency and reduce harmful effects of some chemotherapy.
Capecitabine
Capecitabine is a substance that helps stop certain cancers from growing, commonly used for breast and colorectal cancer.
Fluorouracil
Fluorouracil is a substance used to treat cancer by stopping the growth of cancer cells.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

5-Fluorouracil
5-Fluorouracil Ebewe
5-Fluorouracil Sandoz

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Institut Sainte Catherine
oncologie
Avignon, France
Centre Hospitalier Pierre Oudot
oncology
Bourgoin-Jallieu, France
Clinique De La Sauvegarde
oncology
Champagne-au-Mont-d'Or, France
Sponsor: Institut Gustave Roussy
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.