Rectal Cancer: Valproic Acid with Radiotherapy and Capecitabine

We are studying whether adding valproic acid to standard radiotherapy and capecitabine improves tumor response in patients with low to moderate risk rectal cancer before surgery. This trial also examines the impact on survival and quality of life.

Safety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesOralOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Capecitabine
Capecitabine is a chemotherapy medicine used to treat certain cancers, including breast and colon cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Capecitabine
Capecitabine is a substance that helps stop certain cancers from growing, commonly used for breast and colorectal cancer.
Valproate Semisodium
Valproate semisodium is a substance that helps control seizures and stabilize mood in epilepsy and bipolar disorder.
Valproic Acid
Valproic acid is a substance that helps control seizures and stabilize mood in conditions like epilepsy and bipolar disorder.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Capecel
Capecitabin Al
Capecitabin Amarox

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Azienda Ospedaliera Regionale San Carlo
U O Oncologia Medica
Potenza, Italy
IRCCS Istituto Nazionale Tumori Fondazione Pascale
S.C. Oncologia Clinica Sperimentale Addominale
Soccavo, Italy
Pia Fondazione Di Culto E Religione Card G Panico
UO Oncologia
Tricase, Italy
Sponsor: IRCCS Istituto Nazionale Tumori Fondazione Pascale
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.