Recurrent Brain Tumors in Children: Ultrasound Blood-Brain Barrier Study

We are evaluating a new ultrasound device to safely open the blood-brain barrier before chemotherapy in children with recurrent brain tumors. This study aims to see how well this method works and its effects on tumor progression.

>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesInjectionNeurologyOncologyPediatrics

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Carboplatin
Carboplatin is a chemotherapy medicine used to treat various types of cancer.
Sonovue
SonoVue is a medicine given during ultrasound scans to improve image clarity and help doctors see organs and blood flow.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Carboplatin
Carboplatin is a chemotherapy substance used to treat various cancers by damaging cancer cells and slowing tumor growth.
Sulfur Hexafluoride
Sulfur hexafluoride is a gas used as a temporary eye bubble to help fix detached retinas and to enhance ultrasound imaging.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Carbo-Cell
Carbomedac
Carboplan

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Assistance Publique Hopitaux De Paris
Pediatric Neurosurgery
Montrouge, France
Institut Curie
Pediatric oncology
Paris, France
Institut Gustave Roussy
child and adolescent oncology
Villejuif, France
Sponsor: Assistance Publique Hopitaux De Paris
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.