Recurrent Grade-4 Glioma: Bortezomib and Temozolomide Study

We are studying the safety and effectiveness of combining Bortezomib with Temozolomide for patients with recurrent grade-4 glioma. This research may help improve treatment options for this challenging condition.

3-6 months Safety phase (I)Efficacy phase (II)No Placebo Standard Medicines Oral InjectionOncology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Bortezomib Accord

Bortezomib Accord is a cancer medicine used to treat multiple myeloma and certain types of lymphoma.

Bortezomib Viatris

Bortezomib Viatris is a cancer medicine used to treat multiple myeloma and certain types of lymphoma.

Temozolomide Accord

Temozolomide Accord is a chemotherapy medicine used to treat certain brain tumors.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Bortezomib

Bortezomib is a substance that blocks cellular protein breakdown to treat certain blood cancers, including multiple myeloma.

Temozolomide

Temozolomide is a substance used in chemotherapy to treat certain types of brain tumors by slowing cancer cell growth.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abormib

Adabonib

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Helse Bergen HF

Oncology

Bergen, Norway

Oslo University Hospital HF

Oncology

Oslo, Norway

Universitetssykehuset Nord-Norge HF

Oncology

Tromsø, Norway

Sponsor: Helse Bergen HF

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.