Recurrent Low-Grade Serous Ovarian Cancer: Avutometinib and Defactinib Study

We are studying a new combination therapy for patients with recurrent low-grade serous ovarian cancer to see if it helps them live longer and improves their quality of life compared to standard treatments.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Anastrozol 1 A Pharma
Anastrozol 1 A Pharma is a medicine used to treat certain breast cancers in women after menopause by lowering the body's estrogen levels.
Anastrozol Stada
Anastrozol Stada is a medicine used to treat certain types of breast cancer in women after menopause by lowering estrogen levels.
Caelyx Pegylated Liposomal
Caelyx is a chemotherapy medicine used to treat certain types of cancer by targeting and killing cancer cells.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Anastrozole
Anastrozole is a substance that lowers estrogen levels to help treat and prevent hormone-sensitive breast cancer in postmenopausal women.
Doxorubicin Hydrochloride
Doxorubicin hydrochloride is a chemotherapy substance used to treat various cancers by killing or slowing the growth of cancer cells.
Letrozole
Letrozole is a substance that lowers estrogen to treat certain types of breast cancer in postmenopausal women.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Vs-6063
Vs-6766
Defactinib

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abutrax
Abutrax
Adiunastrol

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...
UZ Leuven
Oncology
Heverlee, Belgium
Universitair Ziekenhuis Gent
Oncology
Ledeberg, Belgium
Centre Hospitalier Universitaire Dinant Godinne Sainte-Elisabeth-UCL-Namur
Oncology
Saint-Servais, Belgium

Sponsor: Verastem Inc.
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.