Relapsed or Refractory Tumors: AcSé-ESMART Trial

We are studying new treatment options for children and adolescents with hard-to-treat tumors. The goal is to see if these treatments are safe and effective based on the specific characteristics of their tumors.

>2 years Safety phase (I)Efficacy phase (II)No Placebo Investigational Medicines Oral InjectionOncologyPediatrics

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Bavencio

Bavencio is a cancer medicine that helps the immune system detect and attack certain tumors.

Temozolomide Viatris

Temozolomide Viatris is a chemotherapy medicine used to treat certain brain cancers.

Vinorelbine

Vinorelbine is a chemotherapy medicine used to treat certain cancers, most commonly lung and breast cancer.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Avelumab

Avelumab is a substance that boosts the immune system to help the body recognize and attack certain types of cancer.

Capivasertib

Capivasertib is a substance that blocks a protein that helps cancer cells grow to help slow certain cancers.

Capmatinib

Capmatinib is a substance that targets MET to treat certain non-small cell lung cancers with MET gene changes.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Enasidenib Mesilate

Inc280

Lee011

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Aderolio

Aderolio 250 Mcg Tablets

Aderolio 500 Mcg Tablets

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...

Rigshospitalet

Paediatrics & Adolescent Medicine

Copenhagen, Denmark

Centre Hospitalier Universitaire D'Angers

Pediatric oncology

Angers, France

Pellegrin Hospital

Onco-Haematological pediatry

Bordeaux, France

Sponsor: Institut Gustave Roussy

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.