Rheumatoid Arthritis: AP1189 with Methotrexate

We are studying a new oral medication, AP1189, for people with early rheumatoid arthritis who haven't received other treatments. The goal is to see if it works better with methotrexate than methotrexate alone.

3-6 months6-10 visitsEfficacy phase (II)Cost ReimbursementInvestigational MedicinesOralRheumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Methotrexat Ebewe
Methotrexat Ebewe is a prescription medicine used to treat some cancers and certain inflammatory conditions like rheumatoid arthritis and severe psoriasis.
Remeron
Remeron is a medicine used to treat depression, helping improve mood, sleep, and appetite.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Methotrexate
Methotrexate is a substance that slows rapid cell growth and calms the immune system to treat certain cancers and autoimmune conditions.
Methotrexate Disodium
Methotrexate disodium is a substance that slows cell growth and suppresses the immune system to treat certain cancers and autoimmune conditions.
Mirtazapine
Mirtazapine is a substance that helps relieve depression and can also improve sleep and reduce anxiety.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Ap1189

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Afloyan
Anchopriv
Auromirta Oro

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical Center Artmed Ltd.
Haskovo, Bulgaria
Diagnostic Consultative Center 1 Lom EOOD
Rheumatology
Lom, Bulgaria
Medical Center Health Care Ltd.
Rheumatology
Petrich, Bulgaria
Sponsor: Synact Pharma ApS
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.