Rheumatoid Arthritis: Baricitinib and Anti-TNF Combination Study

We are investigating whether combining baricitinib with anti-TNF therapy helps patients with rheumatoid arthritis who haven't responded to other treatments. The study will also look at safety and how well patients can reduce their steroid use.

6-12 months 11-15 visits Confirmation phase (III)Post-Trial Drug Access Investigational Medicines Oral InjectionRheumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Benepali

Benepali is a medicine used to treat inflammatory autoimmune conditions such as rheumatoid arthritis and psoriasis.

Enbrel

Enbrel is a medicine that helps reduce immune system–caused inflammation to treat rheumatoid arthritis, psoriatic arthritis, and some types of psoriasis.

Imraldi

Imraldi is a medicine used to treat autoimmune conditions, helping reduce inflammation and control symptoms in diseases like arthritis, psoriasis, and Crohn’s disease.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Adalimumab

Adalimumab is a biologic that blocks a key inflammatory protein (TNF) to reduce inflammation in autoimmune conditions like rheumatoid arthritis and Crohn's disease.

Baricitinib

Baricitinib is a substance that reduces immune-driven inflammation to treat rheumatoid arthritis.

Etanercept

Etanercept is a substance that blocks a protein involved in inflammation to treat autoimmune conditions like rheumatoid arthritis and psoriasis.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Imraldi

Benepali

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Amgevita

Amsparity

Brucorten

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier De La Cote Basque

Rhumatologie

Bayonne, France

University Hospital Of Clermont-Ferrand

Rhumatologie

Beaumont, France

Centre Hospitalier Universitaire De Toulouse

Rhumatologie

Blagnac, France

Sponsor: Centre Hospitalier Universitaire De Bordeaux

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.