Richter Syndrome: GLOfitamab with Chemotherapy

We are studying a new treatment combining GLOfitamab with standard chemotherapy for patients with Richter syndrome. The goal is to see if this combination improves treatment response and safety.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Cortancyl
Cortancyl is a steroid medicine used to reduce inflammation and treat allergies, asthma, and certain autoimmune or inflammatory conditions.
Doxorubicin Accord
Doxorubicin Accord is a chemotherapy medicine used to treat various types of cancer.
Endoxan
Endoxan is a chemotherapy medicine used to treat various types of cancer and some severe autoimmune conditions.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Cyclophosphamide
Cyclophosphamide is a cancer-fighting and immune-suppressing substance used to treat various cancers and some severe autoimmune conditions.
Cyclophosphamide Monohydrate
Cyclophosphamide monohydrate is an anti-cancer substance used to treat various cancers and some serious autoimmune diseases.
Doxorubicin Hydrochloride
Doxorubicin hydrochloride is a chemotherapy substance used to treat various cancers by killing or slowing the growth of cancer cells.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Adriacept Blasen-Instillations-Set
Adriamycin
Adriblastin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire Amiens Picardie
SERVICE HEMATOLOGIE CLINIQUE ET THERAPIE CELLULAIRE
Amiens, France
CENTRE HOSPITALIER DE LA COTE BASQUE
Service d'hématologie
Bayonne, France
Groupe Hospitalier De La Region De Mulhouse Et Sud Alsace
Hématologie
Brunstatt, France

Sponsor: French Innovative Leukemia Organization
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.