Rituximab for Children with Nephrotic Syndrome

We are studying whether early treatment with rituximab helps children with idiopathic nephrotic syndrome stay in remission longer than those receiving a placebo. This trial aims to improve treatment strategies for this condition.

>2 years11-15 visitsConfirmation phase (III)Standard MedicinesInjectionInternal MedicineNephrology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Mabthera
Mabthera is a medicine used to treat certain blood cancers and some autoimmune diseases by targeting problematic immune cells.
Saline
Saline is a sterile saltwater solution used to hydrate patients, replace lost fluids, and rinse wounds or medical equipment.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Rituximab
Rituximab is a substance that targets and reduces B cells, a type of white blood cell, to treat some blood cancers and autoimmune conditions.
Sodium Chloride
Sodium chloride is a substance used to replace salts and fluids in the body and to clean or irrigate wounds and nasal passages.
Sodium Chloride Solution 0.9%
Sodium chloride 0.9% is a sterile salt solution used to replace fluids and electrolytes, hydrate patients, and clean wounds or body cavities.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acuolens
Addex Natriumklorid
Aminoplasmal E

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Medical University Of Bialystok
Klinika Pediatrii i Nefrologii, Uniwersytecki Dziecięcy Szpital Kliniczny w Białymstoku
Białystok, Poland
Uniwersytecki Szpital Dziecięcy w Krakowie
Klinika Nefrologii Dziecięcej
Grzegórzki, Poland
Instytut Centrum Zdrowia Matki Polki
Klinika Pediatrii Immunologii i Nefrologii
Łódź, Poland
Sponsor: Medical University Of Gdansk
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.