Sacubitril/Valsartan for Heart Protection in Breast Cancer Treatment

We are studying whether sacubitril/valsartan can help prevent heart damage in women receiving systemic treatment for breast cancer. This trial aims to understand its potential benefits in protecting heart function during therapy.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Entresto
Entresto is a medicine used to treat heart failure by helping the heart pump better and reducing hospitalizations.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Sacubitril
Sacubitril is a substance that helps improve heart function in people with heart failure by boosting natural heart-protective hormones.
Valsartan
Valsartan is a substance that helps lower high blood pressure and reduces strain on the heart.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Entresto

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Almertan
Alsartir
Amlodipin/Valsartan/Hydrochlorothiazid Ratiopharm

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
Centrum Diagnostyki i Leczenia Chorób Piersi
Gliwice, Poland
Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Kielcach
Zakład Onkokardiologii
Kielce, Poland
Opolskie Centrum Onkologii Im. Prof. Tadeusza Koszarowskiego W Opolu Samodzielny Publiczny Zaklad Opieki Zdrowotnej
Klinika Onkologii z Odcinkiem Dziennym
Opole, Poland

Sponsor: Slaskie Centrum Chorob Serca W Zabrzu
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.