Sepsis Treatment: Hydrocortisone and Fludrocortisone Study

We are investigating whether a combination of hydrocortisone and fludrocortisone can improve outcomes for adults with sepsis in the ICU. This study aims to see if it helps reduce death or ongoing organ issues compared to a placebo.

>2 yearsConfirmation phase (III)Partially RemoteInvestigational MedicinesOralInjectionInfectious DiseasesInternal Medicine

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Betamethasone
Betamethasone is a corticosteroid substance that reduces inflammation and suppresses immune responses for conditions like eczema, allergies, and arthritis.
Fludrocortisone
Fludrocortisone is a hormone-like substance that helps the body retain salt and maintain blood pressure in people with low aldosterone.
Hydrocortisone Hydrogen Succinate
Hydrocortisone hydrogen succinate is a corticosteroid used to reduce inflammation and suppress overactive immune responses in severe allergic or inflammatory conditions.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Fludrocortisone
Hydrocortisone
Hydrocortisone hemisuccinate

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Victor Dupouy
Médecine Intensive - Réanimation
Argenteuil, France
Centre Hospitalier De Bourg-En-Bresse
Médecine Intensive - Réanimation
Bourg-en-Bresse, France
Assistance Publique Hopitaux De Paris
Réanimation Médico-Chirurgicale
Colombes, France
Sponsor: Assistance Publique Hopitaux De Paris
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.