Hospital-Acquired Pneumonia
Hospital-Acquired Pneumonia (HAP) is a type of lung infection that occurs in patients during their stay in a hospital, often caused by bacteria that are resistant to antibiotics.
Serious Bacterial Infections in Children: Aztreonam-Avibactam Study
We are investigating a new treatment for serious gram-negative bacterial infections in children aged 9 months to under 18 years. The study compares this treatment to the best available therapy to assess safety and effectiveness.
≤3 months16-20 visitsEfficacy phase (II)No PlaceboPartially RemoteInvestigational MedicinesInjectionInfectious DiseasesPediatrics
What diseases are being studied?
Health conditions and diseases that the clinical trial is designed to study and treat.
Ventilator-Associated Pneumonia
Ventilator-Associated Pneumonia (VAP) is a lung infection that occurs in people who are on mechanical ventilation, typically caused by bacteria that can thrive in the hospital environment.
Complicated Gram-Negative Bacterial Infections
Complicated gram-negative bacterial infections are severe infections caused by gram-negative bacteria, which can lead to serious health issues and require intensive treatment.
Sepsis
Sepsis is a life-threatening condition caused by the body's response to an infection, leading to tissue damage and organ failure.
Blood Stream Infection
Blood Stream Infection (BSI) occurs when bacteria enter the bloodstream, potentially leading to severe complications like sepsis.
Intra-Abdominal Infection
Intra-abdominal infections occur within the abdominal cavity and can involve organs such as the intestines, liver, or pancreas.
Urinary Tract Infection
A Urinary Tract Infection (UTI) is an infection in any part of the urinary system, often causing painful urination and frequent urges to urinate.
Who can participate in the clinical trial?
These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..
- Are you between 9 months and 18 years old?
- Do you require hospitalization and IV antibiotic treatment?
- Are you pregnant or breastfeeding?
- Have you received systemic antibiotics in the last 48 hours?
- Do you have severe kidney problems (CrCL less than 15 mL/min)?
What experimental substances are being tested?
Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.
Metronidazole
What similar medicines might you know?
Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.
Abimox
Abiox
Actira
Where is the clinical trial being conducted?
Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.
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Oblastni nemocnice Kolin a.s. nemocnice Stredoceskeho kraje
Detske oddeleni
Kolín, Czechia
Krajska zdravotni a.s.
Detske a dorostove oddeleni
Most, Czechia
University General Hospital Of Heraklion
Pediatric Intensive Care
Irákleion, Greece
Sponsor: Pfizer Inc.
Last updated: Nov 26, 2025
Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.